Cytotoxic Activity and Apoptosis Induction of Hypericum scabrum L.
نویسندگان
چکیده
منابع مشابه
Cytotoxic Activity and Apoptosis Induction of Hypericum scabrum L.
BACKGROUND One of the acquired biological hallmarks of tumor multistep development is the resistance of cancer cells to apoptosis; therefore, induction of apoptosis is an important therapeutic approach. Hypericum species are spread throughout the world and have been investigated for their biological properties. OBJECTIVES Our previous studies had demonstrated cytotoxicity of Hypericum scabrum...
متن کاملcytotoxic activity and apoptosis induction of hypericum scabrum l.
conclusions considering the strong historical background about the therapeutic potential of the genus hypericum and the considerable cytotoxic and apoptosis induction ability of hypericum scabrum, this species is suggested for future biological studies. results di-chloromethane fraction demonstrated ic50 values of 25.72 μg/ml and 24.73 μg/ml against ht-29 and hepg-2 cell lines, respectively and...
متن کاملPharmacological activities of Hypericum scabrum L.
OBJECTIVES Hypericum spp. (H.) has been used in traditional medicine for their sedative effect for many years. In spite of many works on this genus, little is known about H. scabrum. In this work antidepressant and its protective effect against hypoxia-induced lethality were evaluated. MATERIALS AND METHODS Antidepressant and its protective effects against hypoxia-induced lethality were evalu...
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The essential oils obtained by hydrodistillation from the aerial parts of Hypericum perforatum L. and Hypericum scabrum L. from plants growing wild in Tajikistan were analyzed by GC-MS. Sixty-six compounds were identified in the essential oils of H. perforatum with germacrene D (13.7%), α-pinene (5.1%), (E)-caryophyllene (4.7%), n-dodecanol (4.5%), caryophyllene oxide (4.2%), bicyclogermacrene ...
متن کاملCytotoxic activity and apoptosis induction by gaillardin.
Cytotoxic activity of gaillardin, a sesquiterpene lactone isolated from Inula oculus-christi L. (Asteraceae), was assessed in the human breast adenocarcinoma cell line MCF-7, human hepatocellular carcinoma cell line HepG-2, human non-small cell lung carcinoma cell line A-549, and human colon adenocarcinoma cell line HT-29, resulting in IC50 values of 6.37, 6.20, 4.76, and 1.81 microg/mL, respec...
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ژورنال
عنوان ژورنال: Iranian Red Crescent Medical Journal
سال: 2015
ISSN: 2074-1804,2074-1812
DOI: 10.5812/ircmj.19453